Path to Collagenolysis
نویسندگان
چکیده
منابع مشابه
Activated Protein C synergises with IL-1 to drive collagenolysis from equine articular cartilage
Introduction: Osteoarthritis (OA) is a chronic, debilitating, degenerative joint disease in which degradation of the ECM macromolecules aggrecan and type II collagen are a major feature. Invitro models of degradation using Oncostatin M (OSM) in combination with Interleukin-1β (IL-1) stimulate collagen breakdown in some species [1, 2]. However, in our preliminary findings, this was not observed ...
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OBJECTIVE Osteoarthritis (OA) is associated with destruction of type II collagen-rich hyaline articular cartilage. We hypothesized that classical interstitial collagenases cleave collagen type II, leading to the increased expression of the 3/4 native type II collagen fragment (COL2-3/4C) and the corresponding denatured type II collagen fragment (COL2-3/4M), which could correlate with different ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.703124